Yazar "Baykal, Ahmet Tarık" için listeleme
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Alzheimer hastalığında yaşa bağlı hipokampusteki protein profil değişimi ile meydana gelen farklılıklar ve ilişkili yolakların transgenik 5XFAD fare modeli üzerinde incelenmesi
Arzuman, Ayşegül Sümeyye (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Alzheimer Hastalığı en yaygın görülen demaslardan biridir. Fakat, hastalığın mekanizması ve hastalıkla ilgili biyobelirteçler henüz tam olarak açıklığa kavuşmamıştır. Bu çalışmada, 5xFAD transgenik fare modeli ve onların ... -
Beyin ekstrasellüler matriksinin nörodejenerasyondaki rolünün alzheimer fare modelinde araştırılması
Gürel, Büşra (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Alzheimer hastalığında (AD), sinaptik yanıt mekanizmalarının ve sinaptik bağlantı stabilitesinin hasar gördüğü bilinmektedir. Son yıllarda yapılan çalışmalar, nöron ve glialar tarafından üretilen bazı ekstrasellüler matriks ... -
Biochemical and proteomic analysis of a potential anticancer agent: Palladium(II) saccharinate complex of terpyridine acting through double strand break formation
Adıgüzel, Zelal; Baykal, Ahmet Tarık; Kaçar, Ömer; Yılmaz, Veysel Turan; Ulukaya, Engin; Açılan, Ceyda (American Chemical Society, 2014)Metal based chemotherapeutic drugs are widely used as an effective method to defeat various cancers. In this study, the mechanism of action of a novel therapeutic agent, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntaş, Ebru; Süzek, Barış Ethem; Şahin, Betül; Parlayan, Cüneyd; Öztürk, Gürkan; Baykal, Ahmet Tarık; Demircan, Turan (Elsevier, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib
Yerlikaya, Azmi; Okur, Emrah; Baykal, Ahmet Tarık; Acılan, Ceyda; Boyacı, İhsan; Ulukaya, Engin (Elsevier, 2014)This data article contains data related to the research article entitled, "A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line" by Yerlikaya et al. [1]. The research ... -
Deneysel çalışmalarda çevresel değişikliğe maruz kalan Fasciola Hepatica'nın salgıladığı protein miktarlarının bir ileri proteomik yaklaşımla incelenmesi
Haçarız, Orçun; Baykal, Ahmet Tarık (Türkiye Parazitoloji Derneği, 2014)Amaç: Ana konakçıdan çıkarıldıktan sonra çevresel değişikliğe maruz kalan Fasciola hepatica'nın salgıladığı protein miktarlarını bir ileri proteomik yaklaşımla incelemek.Yöntemler: Son konakçıdan toplanan ergin F. hepatica ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
Demircan, Turan; Keskin, İlknur; Dumlu, Seda Nilgün; Aytürk, Nilüfer; Avşaroğlu, Mahmut Erhan; Akgün, Emel; Öztürk, Gürkan; Baykal, Ahmet Tarık (Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Determination of stage specific markers for liver fibrosis in hepatitis B: A comparative tissue proteomic study
Katrinli, Şeyma; Özdil, Kamil; Şahin, Aslı; Öztürk, Oğuzhan; Kır, Gözde; Baykal, Ahmet Tarık; Saraç, Ömer Sinan; Sökmen, Mehmet; Dinler Doğanay, Gizem; Doğanay, Hamdi Levent (Elsevier Science B.V., 2016)Background and Aims: Chronic Hepatitis B infection is one of themajor causes of liver cirrhosis and around 600,000 people dieannually worldwide. The virus itself is non-cytopathic and the liverdamage is due to host immune ... -
Early stage alterations in CA1 extracellular region proteins indicate dysregulation of IL6 and iron homeostasis in the 5XFAD Alzheimer's disease mouse model
Gürel, Büşra; Cansev, Mehmet; Sevinç, Cansu; Keleştemur, Seda; Öcalan, Büşra; Çakır, Ayşen; Aydın, Sami; Kahveci, Nevzat; Ozansoy, Mehmet; Taşkapılıoğlu, Özlem; Ulus, İsmail Hakkı; Karayel Başar, Merve; Şahin, Betül; Tüzüner, Mete Bora; Baykal, Ahmet Tarık (Ios Press, 2018)In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer's disease (AD). ... -
Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols
Adıgüzel, Zelal; Arda, Nazlı; Kaçar, Ömer; Serhatlı, Müge; Gezer Taş, Serpil; Baykal, Ahmet Tarık; Baysal, Kemal; Açılan, Ceyda (Springer, 2014)Oxysterols, oxygenated derivatives of cholesterol, are found abundantly in the plasma and atherosclerotic plaques, a common risk factor for thoracic aortic aneurysms (TAAs). Among the oxysterols, namely 7-ketocholesterol ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
Generating a detailed protein profile of Fasciola hepatica during the chronic stage of infection in cattle
Haçarız, Orçun; Baykal, Ahmet Tarık; Akgün, Mete; Kavak, Pınar; Sağıroğlu, Mahmut Şamil; Sayers, Gearoid Patrick (Wiley-Blackwell, 2014)Fasciola hepatica is a trematode helminth causing a damaging disease, fasciolosis, in ruminants and humans. Comprehensive proteomic studies broaden our knowledge of the parasite's protein profile, and provide new insights ... -
Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation
Hatipoğlu, İbrahim; Ercan, Duygu; Açılan, Ceyda; Başalp, Aynur; Durali, Deniz; Baykal, Ahmet Tarık (Elsevier, 2014)Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient ... -
Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer
Çine, Naci; Baykal, Ahmet Tarık; Sünnetçi, Deniz; Cantürk, Zafer; Serhatlı, Müge; Savlı, Hakan (Spandidos Publications, 2014)Breast cancer is the most common cancer among women and accounts for 23% of all female types of cancers. It is well recognized that breast cancer represents a heterogeneous group of tumors, and the molecular events involved ... -
Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
Beker, Mustafa Çağlar; Çağlayan, Berrak; Çağlayan, Ahmet Burak; Kelestemur, Taha; Yalçın, Esra; Çağlayan, Aysun; Kılıç, Ülkan; Baykal, Ahmet Tarık; Reiter, Russel J.; Kılıç, Ertuğrul (Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ... -
mTor Is a signaling hub in cell survival: A mass-spectrometry-based proteomics investigation
Tang, Zhi; Baykal, Ahmet Tarık; Gao, Hui; Quezada, Hernan Concha; Zhang, Haiyan; Bereczki, Erika; Serhatlı, Müge; Baykal, Betül; Acıoğlu, Çiğdem; Wang, Shan; Ioja, Eniko; Ji, Xinying; Zhang, Yan; Guan, Zhizhong; Winblad, Bengt; Pei, Jin-Jing (American Chemical Society, 2014)mTor plays a central role in controlling protein homeostasis and cell survival. Recently, we have demonstrated that perturbations of mTor signaling are implicated in Alzheimer's disease (AD) and that mTor complex 1 (mTorC1) ... -
Neonatal neurodegeneration in alzheimer's disease transgenic mouse model
Mazi, Aişe Rümeysa; Arzuman, Ayşegül Sümeyye; Gürel, Büşra; Şahin, Betül; Tüzüner, Mete Bora; Ozansoy, Mehmet; Baykal, Ahmet Tarık (IOS Press, 2018)Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the ... -
A preliminary proteomic evaluation of smooth muscle cells in thoracic aortic aneurysms
Açılan Ayhan, Ceyda; Baykal, Betül; Serhatlı, Müge; Kaçar, Ömer; Adıgüzel, Zelal; Taş, Serpil; Baysal, Kemal; Baykal, Ahmet Tarık (The Scientific and Technological Research Council of Turkey, 2014)Aortic aneurysm is characterized as localized degeneration of the aorta leading to advanced weakening and widening of the vessel. While the exact mechanisms have yet to be determined, current studies indicate that the ... -
Proteomic analysis of kidney preservation solutions prior to renal transplantation
Çoşkun, Abdurrahman; Baykal, Ahmet Tarık; Kazan, Dilek; Akgöz, Müslüm; Şenal Öztuğ, Merve; Berber, İbrahim; Titiz, İzzet; Bilsel, Gökhan; Kilercik, Hakan; Karaosmanoğlu, Kübra; Çiçek, Müslüm; Yurtsever, İlknur; Yazıcı, Cevat (Public Library Science, 2016)One of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period ... -
Proteomic analysis of liver preservation solutions prior to liver transplantation
Coşkun, Abdurrahman; Baykal, Ahmet Tarık; Öztuğ, Merve; Kazan, Dilek; Kaya, Ekrem; Emiroğlu, Remzi; Yılmaz, Sezai; Dündar, Halit Ziya; Akgöz, Müslüm; Berber, İbrahim; Ak-taş, Hikmet; Bilsel, Gökhan; Karaosmanoğlu, Kübra; Çetiner, Banu; Arslan, Cansu; Yurtsever, İlknur; Yazıcı, Cevat (Bentham Science Publishers Ltd., 2019)Objective: Transplantation is the preferred treatment for patients with endstage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although ...